Week 4 of the 2026 NFL season delivers a full Sunday of betting action, beginning with the Colts and Commanders in London and ending with the Lions visiting the Panthers on Sunday Night Football.
The Sunday schedule features several major betting storylines. The undefeated Chiefs and Raiders meet in Las Vegas, the 3-0 49ers host the Broncos, the Vikings try to remain unbeaten against the winless Dolphins, and the Rams visit Philadelphia with Puka Nacua returning to the lineup.
There are also several important player-prop situations to watch. Jonathan Taylor has one of the highest rushing-yard expectations on the board, Christian McCaffrey is coming off a full practice week for San Francisco, Puka Nacua is expected to return for Los Angeles, and Nico Collins is set to return for Houston after missing two games.
Odds and player props can change before kickoff, so use the numbers below as a current Saturday snapshot and check the final market before placing any wager.
NFL Week 4 Sunday Betting Odds
Saturday Odds Snapshot — October 3, 2026
The following spreads, moneylines and totals reflect the NFL betting market as of Saturday, October 3. Odds can move before kickoff as sportsbooks react to injuries, lineup news, betting action and other market changes.
| Game | Spread | Moneyline | Total |
|---|---|---|---|
| Colts at Commanders | IND -3.5 | IND -187 / WAS +155 | 47 |
| Cardinals at Giants | ARI -1 | ARI -112 / NYG -106 | 44.5 |
| Titans at Ravens | BAL -11.5 | BAL -714 / TEN +509 | 43.5 |
| Patriots at Bills | BUF -6.5 | BUF -324 / NE +258 | 48.5 |
| Jets at Bears | CHI -3 | CHI -156 / NYJ +132 | 43 |
| Jaguars at Bengals | CIN -2.5 | CIN -142 / JAX +120 | 51.5 |
| Cowboys at Texans | HOU -2.5 | HOU -140 / DAL +119 | 47.5 |
| Rams at Eagles | LAR -3 | LAR -162 / PHI +136 | 44 |
| Packers at Buccaneers | GB -4 | GB -188 / TB +157 | 39.5 |
| Dolphins at Vikings | MIN -10.5 | MIN -637 / MIA +469 | 38.5 |
| Chiefs at Raiders | KC -4.5 | KC -222 / LV +184 | 47.5 |
| Chargers at Seahawks | SEA -7 | SEA -334 / LAC +268 | 43 |
| Broncos at 49ers | SF -2.5 | SF -149 / DEN +125 | 46.5 |
| Lions at Panthers | DET -3.5 | DET -193 / CAR +163 | 50.5 |
The latest Saturday market has the Rams-Eagles spread around Los Angeles -3, Kansas City -4.5 at Las Vegas, Seattle -7 against the Chargers and San Francisco around -3 against Denver. The Lions-Panthers total is one of the highest on the board at approximately 51.5 points, while Dolphins-Vikings and Packers-Buccaneers are sitting at just 38.5.
Sunday Early Games
Colts at Commanders — 9:30 a.m. ET
Spread: Colts -3.5
Total: 47.5
The NFL’s London game opens the Sunday betting schedule with Indianapolis visiting Washington.
Jonathan Taylor is one of the most prominent running-back props on the entire Week 4 board. His rushing-yard consensus has been around 90.5, while rush-plus-receiving markets have pushed above 115 yards. DraftKings has Taylor at -310 to score a touchdown, with a 2+ touchdown price around +170.
Daniel Jones has a passing-yard market in the mid-220s, while Marcus Mariota’s number is around 209.5 in consensus markets.
Player props to watch: Jonathan Taylor rushing yards; Jonathan Taylor anytime TD; Tyler Warren receptions.
Betting angle: Taylor’s workload is the most important Indianapolis prop to monitor.
Cardinals at Giants — 1:00 p.m. ET
Spread: Cardinals -2.5
Total: 44.5
Arizona visits New York in a game with a relatively narrow spread and moderate total.
The Giants’ Cam Skattebo has quickly become one of the more prominent touchdown markets on the Sunday board. DraftKings has Skattebo around -135 anytime touchdown, while Trey McBride is around +140.
The Cardinals’ passing game could also receive attention if New York forces Arizona into a higher-volume passing script.
Player props to watch: Cam Skattebo anytime TD; Trey McBride anytime TD; Jacoby Brissett passing yards.
Titans at Ravens — 1:00 p.m. ET
Spread: Ravens -11.5
Total: 42.5
Baltimore is laying one of the largest spreads of the week against Tennessee.
Derrick Henry remains one of the biggest anytime-touchdown favorites on the Week 4 board, with the consensus price around -275. Lamar Jackson also has a 249.5 combined passing/rushing-yard market in current prop markets.
The main question for Tennessee props is game script. If Baltimore takes control early, Henry’s rushing and touchdown opportunities could increase while Tennessee’s passing volume becomes more difficult to project.
Player props to watch: Derrick Henry rushing yards; Derrick Henry anytime TD; Lamar Jackson passing + rushing yards; Zay Flowers anytime TD.
DraftKings currently lists Flowers around +130 to score.
Patriots at Bills — 1:00 p.m. ET
Spread: Bills -6.5
Total: 48.5
Buffalo enters as a substantial home favorite against New England.
Josh Allen and James Cook dominate the Buffalo touchdown markets. Current consensus pricing has Allen around -170 to score and Cook around -164, while DraftKings lists Cook at approximately -135 in its current market.
The discrepancy between books illustrates why comparing prices matters, particularly on popular anytime-touchdown markets.
TreVeyon Henderson is another player worth monitoring. His rushing-yard market is around 39.5 yards in the current prop market.
Player props to watch: Josh Allen anytime TD; James Cook anytime TD; TreVeyon Henderson rushing yards; Dalton Kincaid anytime TD.
Jets at Bears — 1:00 p.m. ET
Spread: Bears -3.5
Total: 43.5
The Jets visit Chicago after losing starting running back Breece Hall to a quadriceps injury.
Hall has been ruled out, leaving Braelon Allen and Isaiah Davis in line for additional work. New York is also without wide receiver Adonai Mitchell and offensive lineman Dylan Parham. Chicago will again be without Caleb Williams, with Tyson Bagent expected to start after clearing concussion protocol.
Allen’s reception and rushing markets become particularly important because of Hall’s absence.
D’Andre Swift is one of the strongest touchdown-market options on the Chicago side, with DraftKings around -120 in its current market.
Player props to watch: Braelon Allen rushing yards; D’Andre Swift anytime TD; Garrett Wilson receiving yards.
Jaguars at Bengals — 1:00 p.m. ET
Spread: Bengals -2.5
Total: 51.5
This is one of the week’s highest-total games and therefore one of the better environments for offensive player props.
Ja’Marr Chase has an anytime-touchdown market around -115, while Chase Brown is around -160 and Tee Higgins around +140 to +150 depending on the sportsbook.
Bhayshul Tuten has also attracted attention in the Jacksonville backfield. His rushing-yard market is around 49.5 and his rush-plus-receiving market around 70.5.
Player props to watch: Ja’Marr Chase receiving yards; Ja’Marr Chase anytime TD; Chase Brown rushing yards; Bhayshul Tuten rushing yards.
Cowboys at Texans — 1:00 p.m. ET
Spread: Texans -3
Total: 48.5
Houston hosts Dallas in a matchup featuring the return of one of the league’s most productive receivers.
Nico Collins is expected to return after missing the previous two games with a hamstring injury. He practiced fully Friday and has no reported game-status restriction.
That immediately makes Collins one of the most interesting receiving props on the board.
CeeDee Lamb is also an important touchdown market, with DraftKings around +130 for an anytime touchdown. Javonte Williams is around -130, while David Montgomery is around -160.
Player props to watch: Nico Collins receiving yards; CeeDee Lamb receiving yards; CeeDee Lamb anytime TD; Javonte Williams anytime TD.
Rams at Eagles — 1:00 p.m. ET
Spread: Rams -3
Total: 43.5
This is one of the most significant games of the early window.
The Rams have moved from a smaller opening favorite to around -3, while Puka Nacua is expected to return after missing time with a hip injury. Aaron Donald, however, has been ruled out with back soreness.
Nacua’s return adds a major receiving weapon to the Rams offense. DraftKings has him around +130 anytime touchdown, while Davante Adams is around +120. Kyren Williams is around -120.
Saquon Barkley is also around +110 to score.
Player props to watch: Puka Nacua receiving yards; Puka Nacua anytime TD; Davante Adams anytime TD; Saquon Barkley rushing yards; Kyren Williams rushing yards.
Sunday Afternoon Games
Packers at Buccaneers — 1:00 p.m. ET
Spread: Packers -3.5
Total: 38.5
This is one of the lowest-total games of the week.
The injury report is important for Tampa Bay. Baker Mayfield has been ruled out with a thumb injury, meaning the Buccaneers will turn to their backup quarterback. Bucky Irving is healthy and available.
The low total makes touchdown markets more difficult, but it also puts additional emphasis on running-back volume.
Tucker Kraft is around +250 to score an anytime touchdown in the current DraftKings market.
Player props to watch: Bucky Irving rushing/receiving yards; Tucker Kraft anytime TD; Packers running-back rushing props.
Dolphins at Vikings — 4:05 p.m. ET
Spread: Vikings -10.5
Total: 38.5
Miami enters the game 0-3 while Minnesota is 3-0.
The Vikings have been one of the stronger against-the-spread teams early in the season, while Miami has struggled to produce consistently on offense. NBC’s Friday market snapshot had Minnesota -10.5 with a 38.5 total.
Aaron Jones is one of the principal Minnesota touchdown options and is priced around -155 in the current DraftKings market.
Player props to watch: Aaron Jones rushing yards; Aaron Jones anytime TD; Malik Willis passing yards; Minnesota team total.
Chiefs at Raiders — 4:25 p.m. ET
Spread: Chiefs -4.5
Total: 47.5
This matchup features two undefeated teams, with Kansas City and Las Vegas both entering at 3-0.
Patrick Mahomes is available without an injury designation, while Rashee Rice has also practiced fully. Kansas City does have offensive tackle Josh Simmons ruled out. Las Vegas has Brock Bowers limited with a foot issue, while quarterback Aidan O’Connell is questionable for personal reasons.
Kenneth Walker III has quickly become an important Kansas City touchdown option, while Brock Bowers is around +160 to +180 to score depending on the current book.
Player props to watch: Patrick Mahomes passing yards; Rashee Rice receiving yards; Kenneth Walker III rushing yards; Brock Bowers receiving yards; Brock Bowers anytime TD.
A current rush-plus-receiving line for Walker is approximately 112.5 yards.
Chargers at Seahawks — 4:25 p.m. ET
Spread: Seahawks -7
Total: 42.5
Seattle enters as a significant home favorite against an 0-3 Chargers team.
Jaxon Smith-Njigba remains one of the most important Seattle receiving props, while Kenneth Walker III is expected to be heavily involved in the ground game.
DraftKings currently has Smith-Njigba around +450 for two or more touchdowns, while consensus touchdown pricing has him around -118 to score once.
The Chargers have several injury questions, including Justin Herbert’s backup Trey Lance, Derwin James and Ladd McConkey.
Player props to watch: Jaxon Smith-Njigba receiving yards; Jaxon Smith-Njigba anytime TD; Justin Herbert passing yards; Omarion Hampton rushing yards.
Broncos at 49ers — 4:25 p.m. ET
Spread: 49ers -3
Total: 47.5
This is arguably the most intriguing late-afternoon matchup.
San Francisco is 3-0, while Denver is 2-1. The 49ers will be without Nick Bosa, but Christian McCaffrey practiced fully and has no injury designation.
McCaffrey is around -180 to -240 to score an anytime touchdown depending on the sportsbook, making him one of the week’s biggest touchdown favorites.
George Kittle is another prominent San Francisco prop, with an anytime-touchdown price around +165.
On Denver’s side, Bo Nix faces a San Francisco defense without Bosa but still has to deal with a 49ers defense that can create pressure through multiple fronts.
Player props to watch: Christian McCaffrey rushing yards; Christian McCaffrey anytime TD; George Kittle receiving yards; George Kittle anytime TD; Bo Nix passing yards.
One current analyst prop has Bo Nix under 225.5 passing yards, while Kittle’s receiving-yard line is around 64.5.
Lions at Panthers — 8:20 p.m. ET
Spread: Lions -3.5
Total: 51.5
The Sunday Night Football matchup brings the highest total of the day, with Detroit visiting Carolina.
The Lions enter 2-1, while Carolina is 1-2. The current total around 51.5 suggests a substantially more offense-oriented matchup than several of the afternoon games.
Jahmyr Gibbs is one of the biggest prop names on the board. His current rush-plus-receiving line is approximately 135.5 yards, while his touchdown market has moved into heavy-favorite territory. DraftKings currently lists Gibbs around +155 for two touchdowns, while consensus anytime-touchdown pricing is around -325.
Amon-Ra St. Brown is another major touchdown-market player at around -120.
Detroit’s injury report is relatively clean, with guard Ben Bartch ruled out and D.J. Reed questionable.
Player props to watch: Jahmyr Gibbs rushing yards; Jahmyr Gibbs rushing + receiving yards; Amon-Ra St. Brown receiving yards; Amon-Ra St. Brown anytime TD; Chuba Hubbard rushing yards.
Top NFL Week 4 Player Props
Several player props stand out across Sunday’s schedule because of workload, matchup or injury-related changes.
Jonathan Taylor Anytime Touchdown
Jonathan Taylor anytime TD: approximately -310
Taylor has one of the largest projected workloads on the Sunday board and is the centerpiece of Indianapolis’ rushing attack.
Derrick Henry Anytime Touchdown
Derrick Henry anytime TD: approximately -275
Baltimore is a massive favorite against Tennessee, making Henry’s goal-line workload particularly important to the touchdown market.
Christian McCaffrey Anytime Touchdown
Christian McCaffrey anytime TD: approximately -180 to -240
McCaffrey is fully healthy entering the game and remains central to San Francisco’s offense.
Puka Nacua Anytime Touchdown
Puka Nacua anytime TD: approximately +130
Nacua’s return is one of the biggest player-news developments of the week. He caught five passes for 74 yards in his only game this season before his hip injury.
Saquon Barkley Anytime Touchdown
Saquon Barkley anytime TD: approximately +110
Philadelphia’s home matchup against Los Angeles creates an interesting environment for Barkley’s rushing and touchdown markets.
Jahmyr Gibbs Anytime Touchdown
Jahmyr Gibbs anytime TD: approximately -120 to -325 depending on sportsbook/market
The wide range illustrates why sportsbook comparison is particularly important on touchdown props. Consensus markets have Gibbs as one of the strongest touchdown favorites of Week 4.
NFL Week 4 Prop Parlay Ideas
Running Back Touchdown Parlay
Jonathan Taylor anytime TD + Derrick Henry anytime TD + Christian McCaffrey anytime TD
This is a three-leg running-back touchdown combination centered on players with prominent workloads.
High-Scoring Game Parlay
Jaguars-Bengals Over 51.5 + Ja’Marr Chase anytime TD
The game has one of Sunday’s highest totals, while Chase is one of the most heavily priced Cincinnati touchdown options.
Rams-Eagles SGP
Puka Nacua anytime TD + Saquon Barkley anytime TD
Both players are priced in the plus-money range, making this a higher-variance touchdown combination.
Sunday Night Football SGP
Lions -3.5 + Jahmyr Gibbs anytime TD + Amon-Ra St. Brown anytime TD
This is built around Detroit controlling the game while its two principal offensive weapons contribute touchdowns.
NFL Week 4 Betting Strategy
The biggest theme entering Sunday’s games is line movement caused by injuries and changing player availability.
Puka Nacua’s return changes the Rams-Eagles offensive picture, while Aaron Donald’s absence changes the Los Angeles defensive matchup. Nico Collins returning is equally important for the Cowboys-Texans game.
Quarterback situations also need to be checked before betting props. Chicago will start Tyson Bagent against the Jets, while Tampa Bay will be without Baker Mayfield against Green Bay.
The other major consideration is the spread itself. Several games are sitting close to key numbers: Rams -3, Texans -3, 49ers -3 and Lions -3.5. Getting the right side of three can matter significantly if a game finishes with a field-goal margin.
Player props also deserve particular attention this week because several backfields have changed due to injuries. Breece Hall’s absence elevates Braelon Allen, Rico Dowdle’s absence affects Pittsburgh’s backfield, and returning players such as Nacua and Collins create new receiving opportunities.
NFL Week 4 Sunday Picks and Predictions
The Sunday slate offers a mixture of large favorites, close divisional games and several high-total matchups.
Early-game spread lean: Ravens -11.5
Early-game prop watch: Jonathan Taylor anytime TD
Best late-afternoon prop watch: Christian McCaffrey anytime TD
High-total game to watch: Jaguars at Bengals
Best receiving prop situation: Puka Nacua returning against Philadelphia
Sunday Night Football prop watch: Jahmyr Gibbs anytime TD
Sunday Night Football spread lean: Lions -3.5
Sunday Night Football total: Over 51.5 is the higher-scoring game scenario to monitor.
Projected Sunday Night Football score: Lions 30, Panthers 24
The most important final step is checking the inactive lists and the latest odds before kickoff. Saturday’s market can still move substantially by Sunday morning, particularly for games affected by quarterback, offensive-line or skill-position injuries.
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