NFL Week 5 Betting Odds: Sunday Spreads, Player Props & Parlays

NFL Week 5 brings a full Sunday slate of betting opportunities, beginning with the Philadelphia Eagles and Jacksonville Jaguars in London and finishing with the Baltimore Ravens visiting the Atlanta Falcons on Sunday Night Football. The schedule features several important quarterback storylines, including a depleted Philadelphia offense, a Cincinnati passing game dealing with injury concerns, and Baltimore preparing to play without Lamar Jackson.

The most interesting matchups for bettors include the Eagles-Jaguars game overseas, the NFC North showdown between the Chicago Bears and Green Bay Packers, Detroit’s high-total matchup against Arizona, and San Francisco’s visit to Seattle. The Falcons-Ravens game also deserves close attention after Jackson was ruled out with an ankle injury, leaving Tyler Huntley to start for Baltimore.

This preview covers the latest available spreads, moneylines and over/under totals, along with player props, anytime-touchdown bets, same-game parlays and score predictions for all 13 Sunday games. Odds are a market snapshot rather than guaranteed prices, and player-prop availability varies by sportsbook.

NFL Week 5 Sunday Betting Odds

Saturday Odds Snapshot — October 10, 2026

The following spreads, moneylines and totals reflect the Saturday betting market. Odds can move before kickoff as sportsbooks react to injury news, lineup announcements, betting action and other market changes. Prices may differ between sportsbooks.

Sunday matchup	Spread	Moneyline	Over/Under
Eagles at Jaguars — 9:30 a.m. ET	JAX -7.5	PHI +315 / JAX -385	41.5
Bengals at Dolphins — 1 p.m. ET	CIN -7	CIN -319 / MIA +280	43.5
Raiders at Patriots — 1 p.m. ET	NE -3.5	LV +164 / NE -192	45.5
Vikings at Saints — 1 p.m. ET	MIN -1.5	MIN -134 / NO +120	42.5
Browns at Jets — 1 p.m. ET	NYJ -1.5	CLE +115 / NYJ -134	39.5
Colts at Steelers — 1 p.m. ET	PIT -2.5	IND +124 / PIT -144	43.5
Texans at Titans — 1 p.m. ET	HOU -7	HOU -355 / TEN +295	38.5
Giants at Commanders — 1 p.m. ET	WAS -3.5	NYG +160 / WAS -170	42.5
Bears at Packers — 1 p.m. ET	CHI -1.5	CHI -122 / GB +105	46.5
Broncos at Chargers — 4:05 p.m. ET	DEN -3.5	DEN -186 / LAC +160	42.5
Lions at Cardinals — 4:25 p.m. ET	DET -5.5	DET -244 / ARI +205	54.5
49ers at Seahawks — 4:25 p.m. ET	SEA -3	SF +146 / SEA -162	46.5
Ravens at Falcons — 8:20 p.m. ET	ATL -3	BAL +150 / ATL -172	43.5

The biggest market story is Baltimore’s quarterback change. The Falcons were already favored at home, but Jackson’s absence makes Atlanta a more appealing side to consider. Detroit-Arizona has the highest total on the Sunday slate at 54.5, while Houston-Tennessee has the lowest at 38.5.

The odds above are drawn from the latest available Week 5 market listings and may differ slightly from the numbers at your sportsbook. Recheck the current line before placing a wager.

Sunday Early Game: Eagles at Jaguars

Kickoff: 9:30 a.m. ET
Location: Tottenham Hotspur Stadium, London
Spread: Jaguars -7.5
Moneyline: Eagles +315; Jaguars -385
Total: 41.5

Jacksonville enters this international matchup in the stronger position, but Philadelphia’s injury situation is a major factor. Running back Saquon Barkley and wide receiver DeVonta Smith are out, along with Marquise Brown. Those absences remove important pieces of the Eagles’ offensive production and could make it harder for Jalen Hurts to sustain drives.

Jacksonville has a favorable opportunity to control the game through its offense, particularly if Bhayshul Tuten continues to receive a substantial share of the backfield work. The Jaguars’ defense should also benefit if Philadelphia struggles to establish its usual balance.

Player props to watch:

Trevor Lawrence passing yards: The current consensus line is around 229.5 yards. Consider the Over only if Jacksonville’s passing matchup and game script support continued volume.
Parker Washington receiving yards: A market around 59.5 yards makes Washington a notable Jacksonville receiving option.
Bhayshul Tuten anytime touchdown: Tuten is a leading touchdown candidate for Jacksonville, with first-touchdown odds listed around +400 at BetMGM. Check the separate anytime-touchdown price before betting.

Prediction: Jaguars 24, Eagles 17.

Betting lean: Jaguars -7.5. The absence of Barkley and Smith makes Philadelphia’s path to keeping this close more difficult, although laying more than a touchdown always carries backdoor-cover risk.

Bengals at Dolphins

Kickoff: 1 p.m. ET
Spread: Bengals -7
Moneyline: Bengals -319; Dolphins +280
Total: 43.5

Cincinnati is favored by a touchdown against a Miami team still searching for its first win. The biggest concern for the Bengals is the status of their receiving corps: Ja’Marr Chase and Tee Higgins are both questionable after appearing on the injury report. Neither should be treated as a confirmed prop recommendation until the final inactive list is available.

Miami’s defense has an opportunity to keep this competitive if Cincinnati’s passing attack is short-handed. However, the Dolphins must also find enough offense to take advantage of any limitations in the Bengals’ lineup.

Player props to watch:

Mike Gesicki anytime touchdown: His touchdown market is listed around +275, making him a longer-price option rather than a conservative pick.
Cincinnati passing props: Wait for the official status of Chase and Higgins before considering their receiving-yard or reception totals.
Miami quarterback passing yards: A potential volume-based angle if the Dolphins fall behind, but compare the posted line and price rather than assuming the game script guarantees an Over.

Prediction: Bengals 24, Dolphins 17.

Betting lean: Bengals -7, with caution around the passing-game props until Cincinnati’s receiver availability is confirmed.

Raiders at Patriots

Kickoff: 1 p.m. ET
Spread: Patriots -3.5
Moneyline: Raiders +164; Patriots -192
Total: 45.5

New England has home-field advantage and is favored by 3.5 points, but Las Vegas enters with a respectable 3-1 record. This is a matchup where the turnover battle and red-zone efficiency could matter more than raw passing-yardage totals.

The Raiders have a key injury concern of their own: running back Ashton Jeanty is questionable with a hamstring issue. If he is limited or unavailable, Las Vegas could have to redistribute carries and receiving opportunities.

New England also has a lengthy injury report, including several defensive backs and running back Rhamondre Stevenson listed as questionable. Check the final availability updates before considering either team’s running-back props.

Player props to watch:

Drake Maye passing yards: A potential option if New England needs to throw to protect a lead or respond to Raiders scoring.
Ashton Jeanty rushing yards: Avoid committing to an Over until his status and expected workload are clear.
Patriots receiving props: Consider a reception-based market for a primary target if the final lineup leaves a clear volume leader.

Prediction: Patriots 24, Raiders 20.

Betting lean: Patriots to win, but Raiders +3.5 is worth considering if the market continues to offer more than a field goal.

Vikings at Saints

Kickoff: 1 p.m. ET
Spread: Vikings -1.5
Moneyline: Vikings -134; Saints +120
Total: 42.5

Minnesota arrives unbeaten at 4-0, while New Orleans is 1-3. The Vikings are slight road favorites, but their injury report creates uncertainty around the passing game. Justin Jefferson and Jordan Addison are questionable, and left tackle Christian Darrisaw is out.

Those absences could affect both quarterback efficiency and the Vikings’ ability to protect the pocket. New Orleans has its own concerns, with Alvin Kamara questionable because of a back injury and linebackers Kaden Elliss and Anfernee Jennings ruled out.

Player props to watch:

Aaron Jones anytime touchdown: Listed around -120 in the current DraftKings market. Confirm his workload and status before betting.
Justin Jefferson receiving yards: His questionable designation makes this a wait-and-see market rather than a recommended pregame Over.
Alvin Kamara rushing or receiving props: Check his final status before considering any market involving his workload.

Prediction: Vikings 23, Saints 20.

Betting lean: Vikings moneyline, but the injury situation makes this a game to approach cautiously. The Under 42.5 is worth monitoring if Minnesota’s receiving corps remains depleted.

Browns at Jets

Kickoff: 1 p.m. ET
Spread: Jets -1.5
Moneyline: Browns +115; Jets -134
Total: 39.5

This is one of the lower-scoring matchups on the board, with a total of just 39.5. Cleveland has a 3-1 record, while the Jets are 1-3, but the Browns have several defensive-line absences that could affect their ability to pressure the quarterback.

The Jets will be without running back Breece Hall, who is out with a quadriceps injury. His absence changes the backfield picture and makes it important to verify which New York running back is expected to receive the most touches.

Player props to watch:

Quinshon Judkins anytime touchdown: Listed around +165. This is a plus-money option, not a guarantee of a high-volume workload.
Garrett Wilson receiving yards: His current consensus line is around 68.5 yards. The Over is worth considering if the Jets need to throw frequently.
Jets replacement running-back props: Check the final depth chart and posted lines after Hall’s absence is reflected in the market.

Prediction: Jets 20, Browns 17.

Betting lean: Under 39.5, although a low total leaves little room for defensive or special-teams touchdowns before the bet becomes uncomfortable.

Colts at Steelers

Kickoff: 1 p.m. ET
Spread: Steelers -2.5
Moneyline: Colts +124; Steelers -144
Total: 43.5

Pittsburgh is a short home favorite in a matchup that could be decided by a handful of plays. Indianapolis has several players listed as questionable, including wide receivers Keenan Allen and Darius Slayton and cornerback Charvarius Ward. Pittsburgh will be without wide receiver Michael Pittman, cornerback Jamel Dean and safety DeShon Elliott.

Running back Rico Dowdle is questionable for the Steelers, so bettors should verify his status before considering Pittsburgh rushing props. The defensive absences on both sides also create the possibility of more productive passing drives than the total might suggest.

Player props to watch:

Jonathan Taylor rushing yards: A natural market to evaluate if Indianapolis can keep the game close and maintain its usual run-game volume.
Pittsburgh passing props: Consider the quarterback’s passing-yard or completion market if the Colts force the Steelers to answer through the air.
Anytime touchdown markets: Prioritize confirmed red-zone roles rather than relying on a player’s recent touchdown result.

Prediction: Steelers 23, Colts 20.

Betting lean: Steelers -2.5, with the Colts moneyline a possible small underdog alternative for bettors who expect a close finish.

Texans at Titans

Kickoff: 1 p.m. ET
Spread: Texans -7
Moneyline: Texans -355; Titans +295
Total: 38.5

Houston and Tennessee enter this matchup at 0-4, making this a critical early-season game for both teams. The Texans are favored by a touchdown, but the low total points toward a game in which scoring opportunities may be limited.

Houston will be without wide receiver Tank Dell, while several offensive linemen are questionable. Those injuries could affect protection and the passing game’s ability to create explosive plays. Tennessee has safety Amani Hooker ruled out, with wide receiver Carnell Tate listed as questionable.

Player props to watch:

David Montgomery anytime touchdown: Listed around +115 in the current DraftKings market. Confirm the player’s role and team listing at your sportsbook before using this price.
Quarterback passing-yard Unders: A low total of 38.5 makes this a market worth evaluating, especially if offensive-line injuries limit downfield opportunities.
Running-back rushing yards: In a projected lower-scoring game, a clear lead back with a stable workload may be preferable to speculative receiving props.

Prediction: Texans 20, Titans 16.

Betting lean: Under 38.5. Houston is the more attractive side, but a touchdown spread in a low-total game can be difficult to cover.

Giants at Commanders

Kickoff: 1 p.m. ET
Spread: Commanders -3.5
Moneyline: Giants +160; Commanders -170
Total: 42.5

Washington is favored at home, but the Giants arrive with a 3-1 record compared with Washington’s 1-3 mark. The Commanders will be without quarterback Marcus Mariota and wide receiver Stefon Diggs, while Terry McLaurin is questionable with a hamstring injury.

That uncertainty makes Washington’s passing props particularly sensitive to the final lineup. If McLaurin cannot play or is limited, the team could need to spread targets more widely.

Player props to watch:

Terry McLaurin receiving yards: Wait for his final status before betting this market.
Giants quarterback passing yards: A possible volume angle if Washington’s defense forces New York to keep scoring.
Running-back touchdown markets: Check the current goal-line depth chart and price rather than relying on last week’s scoring totals.

Prediction: Commanders 23, Giants 20.

Betting lean: Giants +3.5 if the number remains available. Washington’s injury situation makes laying the points less appealing.

Bears at Packers

Kickoff: 1 p.m. ET
Spread: Bears -1.5
Moneyline: Bears -122; Packers +105
Total: 46.5

The NFC North rivalry is one of the more intriguing games of the early window. Chicago is favored by a small margin, but quarterback Caleb Williams is questionable with a hamstring injury. Green Bay also has offensive-line concerns, with Aaron Banks listed as doubtful and other linemen questionable.

Williams’ status is central to the handicap. If he plays without a meaningful limitation, the Bears have the passing ability to attack Green Bay. If he is limited or unavailable, the Packers’ home-field advantage becomes more important.

Player props to watch:

Christian Watson anytime touchdown: Listed around +170 in the current DraftKings market.
Caleb Williams passing yards: Do not bet the Over until his active status and expected mobility are clearer.
Jordan Love passing yards: A market worth evaluating if Green Bay’s offensive line can protect him and Chicago forces the Packers to keep throwing.

Prediction: Bears 24, Packers 23.

Betting lean: Bears moneyline, but the best approach is to wait for confirmation on Williams. At this short price, the quarterback news can change the value substantially.

Broncos at Chargers

Kickoff: 4:05 p.m. ET
Spread: Broncos -3.5
Moneyline: Broncos -186; Chargers +160
Total: 42.5

Denver is favored on the road against a Chargers team that has started the season 0-4. The Broncos have a significant defensive advantage if they can pressure the quarterback, but they will be without cornerbacks Riley Moss and Patrick Surtain II.

The Chargers have a longer list of absences, including wide receiver Quentin Johnston, offensive tackle Joe Alt and safety Derwin James. Ladd McConkey is questionable, and his status could affect the Chargers’ passing-game outlook.

Player props to watch:

Bo Nix passing yards: Consider the Over only if the Chargers can generate enough offense to keep Denver throwing.
Ladd McConkey receiving yards: Verify his final status before considering a prop.
Broncos running-back rushing yards: A potential game-script angle if Denver builds a lead and leans on the ground game.

Prediction: Broncos 24, Chargers 17.

Betting lean: Broncos -3.5. Denver has the more reliable path to controlling the game, though its missing cornerbacks create some risk of explosive plays by Los Angeles.

Lions at Cardinals

Kickoff: 4:25 p.m. ET
Spread: Lions -5.5
Moneyline: Lions -244; Cardinals +205
Total: 54.5

This is the highest-total game on Sunday’s slate and one of the most appealing environments for offensive player props. Detroit is favored by more than a field goal, but Arizona has enough offensive potential to contribute to a high-scoring game.

The 54.5-point total suggests the market expects multiple scoring drives from both teams. That makes receiving yards, receptions and touchdown markets worth examining, especially for players with stable target shares.

Player props to watch:

Amon-Ra St. Brown 80+ receiving yards: A notable alternate-yardage target; CBS Sports’ current prop analysis highlights his consistent target volume.
Amon-Ra St. Brown anytime touchdown: Listed around -140 at DraftKings.
Trey McBride anytime touchdown: Listed around +110, making him a notable Arizona scoring option.

Prediction: Lions 31, Cardinals 27.

Betting lean: Over 54.5 is worth considering, but this is a high threshold. Detroit -5.5 is another option if you expect the Lions to win while Arizona contributes enough points to keep the game competitive.

49ers at Seahawks

Kickoff: 4:25 p.m. ET
Spread: Seahawks -3
Moneyline: 49ers +146; Seahawks -162
Total: 46.5

Seattle is a three-point home favorite in a key NFC West matchup. The Seahawks’ passing defense has been strong, making San Francisco’s receiving props less attractive than they might be against a weaker secondary.

Seattle’s offense, on the other hand, features one of the slate’s highest receiving-yard projections. Jaxon Smith-Njigba has a current receiving-yard line around 93.5 yards, with the Over and Under both priced near -113.

Player props to watch:

Jaxon Smith-Njigba Over 93.5 receiving yards (-113): His high target share makes him a central prop to evaluate, although the yardage requirement is substantial.
Jaxon Smith-Njigba anytime touchdown: Listed around -110 in the current DraftKings market.
George Kittle Over 56.5 receiving yards: A current market line, but Seattle’s strong pass defense makes this a more cautious consideration.

Prediction: Seahawks 24, 49ers 20.

Betting lean: Seahawks -3. Seattle has home-field advantage and a defense that can make life difficult for San Francisco’s passing attack. The Smith-Njigba receiving-yard Over is a secondary option rather than a must-play.

Sunday Night Football: Ravens at Falcons

Kickoff: 8:20 p.m. ET
Spread: Falcons -3
Moneyline: Ravens +150; Falcons -172
Total: 43.5

The biggest news for Sunday Night Football is that Lamar Jackson has been ruled out with an ankle injury. Tyler Huntley is expected to start for Baltimore after replacing Jackson in last week’s win over Tennessee.

Jackson’s absence changes the entire matchup. Baltimore loses its most dynamic offensive player, and the Ravens may need to lean more heavily on Derrick Henry and shorter throws. Atlanta has shown improved offensive form since Michael Penix Jr. returned, and the Falcons will have a significant opportunity at home.

Player props to watch:

Derrick Henry anytime touchdown: Listed around -150 in the current DraftKings market. Henry should remain central to Baltimore’s red-zone offense, although Atlanta can focus more defensive attention on the run with Jackson out.
Bijan Robinson anytime touchdown: Listed around -230. The price is steep, so compare it with Robinson’s rushing-yard alternatives before committing.
Drake London receiving yards: His current consensus line is around 82.5 yards, with the Over and Under near -114.
Zay Flowers receiving yards: His line is around 66.5 yards, but Flowers is questionable with a foot injury. Wait for his official status before considering the Over.

Prediction: Falcons 24, Ravens 17.

Betting lean: Falcons -3. Jackson’s absence is the decisive factor. Atlanta has the more stable quarterback situation and has been playing better offense since Penix returned.

Best NFL Week 5 Player Props

The most appealing props on the Sunday slate combine a clear role with a reasonable market number. The following options stand out for further comparison, but prices can change and should be checked at the sportsbook before betting.

Passing and Receiving Props

Trevor Lawrence Over 229.5 passing yards: Consider if Jacksonville maintains its normal passing volume against Philadelphia.
Parker Washington Over 59.5 receiving yards: A Jacksonville receiving option with a meaningful current projection.
Jaxon Smith-Njigba Over 93.5 receiving yards (-113): Seattle’s primary high-volume receiving target, though the line is demanding.
Amon-Ra St. Brown 80+ receiving yards: An alternate-yardage option in a game with a 54.5-point total.
Drake London Over 82.5 receiving yards: A potential target-volume play for Atlanta, provided the market remains near this line.

Anytime Touchdown Props

Bhayshul Tuten: A leading Jacksonville touchdown candidate in London.
Christian Watson (+170): A plus-money option for Green Bay against Chicago.
Amon-Ra St. Brown (-140): A prominent Detroit touchdown option.
Trey McBride (+110): A plus-money Arizona target against Detroit.
Derrick Henry (-150): Baltimore’s leading touchdown candidate even with Jackson out.
Bijan Robinson (-230): A high-probability but expensive touchdown market.

Touchdown prices are especially sensitive to game script and red-zone usage. A short price does not automatically make a prop good value, and a plus-money price does not automatically make a long shot attractive.

NFL Week 5 Parlay Ideas

Sunday Favorites Parlay

Jaguars moneyline + Patriots moneyline + Falcons moneyline

This parlay combines three teams favored by the market. Jacksonville has a favorable matchup against a depleted Philadelphia offense, New England is a home favorite, and Atlanta gets Baltimore without Jackson.

The risk is that a three-leg parlay requires every selection to win. Consider the individual prices before combining them.

Receiving Production Parlay

Jaxon Smith-Njigba 70+ receiving yards + Amon-Ra St. Brown 60+ receiving yards

This uses alternate receiving-yard lines rather than requiring both players to exceed their full standard projections. The Detroit-Arizona total supports the possibility of a productive passing game, while Smith-Njigba remains Seattle’s key receiving target.

Touchdown Parlay

Bhayshul Tuten anytime TD + Amon-Ra St. Brown anytime TD

Tuten has a significant role in Jacksonville’s red-zone rushing game, while St. Brown is a primary Detroit scoring option. Check both anytime-touchdown prices before combining them.

NFL Week 5 Same Game Parlay Ideas

Eagles at Jaguars SGP

Jaguars moneyline + Bhayshul Tuten anytime touchdown

This is built around Jacksonville winning while its lead running back contributes in the red zone. Philadelphia’s absences make the Jaguars the more attractive side, but the SGP still depends on Tuten getting the necessary scoring opportunity.

Lions at Cardinals SGP

Over 54.5 + Amon-Ra St. Brown 60+ receiving yards

This targets a high-scoring game in which Detroit’s passing game contributes to the total. The risk is that the full-game total is already elevated and could be difficult to clear if one offense stalls.

Ravens at Falcons SGP

Falcons moneyline + Bijan Robinson anytime touchdown

Atlanta’s home-field advantage and Baltimore’s quarterback change support the Falcons side. Robinson provides a second route to a winning ticket, but his anytime-touchdown price is expensive and should be compared with alternate rushing-yard markets.

Featured Game of the Week: Lions at Cardinals

Detroit-Arizona stands out as the featured matchup because its 54.5-point total is the highest on the slate. Both teams have paths to scoring, and the market offers several ways to approach the game beyond the spread.

Detroit is favored by 5.5 points, while the Cardinals are available at +205 on the moneyline. The Lions are the more straightforward side, but Arizona’s ability to score makes the total and receiving props especially interesting.

Amon-Ra St. Brown is a key Detroit target, with an 80+ receiving-yard alternate and an anytime-touchdown market worth comparing. For Arizona, Trey McBride is an intriguing touchdown option at approximately +110. The primary risk to the Over is that Detroit takes control early and shifts toward a run-heavy approach, or that Arizona cannot keep pace.

Featured-game prediction: Lions 31, Cardinals 27.

Preferred angle: Amon-Ra St. Brown 60+ receiving yards as an alternate prop, rather than forcing the full-game Over at 54.5.

NFL Week 5 Sunday Predictions

Matchup	Score prediction	Preferred betting angle
Eagles at Jaguars	Jaguars 24, Eagles 17	Jaguars -7.5
Bengals at Dolphins	Bengals 24, Dolphins 17	Bengals -7, pending receiver news
Raiders at Patriots	Patriots 24, Raiders 20	Patriots to win
Vikings at Saints	Vikings 23, Saints 20	Vikings moneyline
Browns at Jets	Jets 20, Browns 17	Under 39.5
Colts at Steelers	Steelers 23, Colts 20	Steelers -2.5
Texans at Titans	Texans 20, Titans 16	Under 38.5
Giants at Commanders	Commanders 23, Giants 20	Giants +3.5
Bears at Packers	Bears 24, Packers 23	Bears moneyline, pending QB news
Broncos at Chargers	Broncos 24, Chargers 17	Broncos -3.5
Lions at Cardinals	Lions 31, Cardinals 27	Amon-Ra St. Brown alternate receiving yards
49ers at Seahawks	Seahawks 24, 49ers 20	Seahawks -3
Ravens at Falcons	Falcons 24, Ravens 17	Falcons -3

These are matchup projections, not guarantees. Injury news, turnovers, weather, and late line movement can change the best betting angle.

NFL Week 5 Betting Strategy

The most important step before betting Sunday’s slate is checking the final inactive lists. Several games have meaningful uncertainty at quarterback, wide receiver and running back, and those absences can change both game lines and player-prop value. In particular, verify Caleb Williams’ status for Chicago, the availability of Cincinnati’s receivers, Minnesota’s passing-game health, and Zay Flowers’ status for Baltimore.

For spreads, be especially careful with low-total games. A favorite laying seven points in a game with a total below 40 has less margin for error than a favorite in a projected shootout. In higher-total matchups such as Detroit-Arizona, receiving yards and touchdown props may offer alternatives to taking a large spread, but the market can already account for the expected scoring environment.

For parlays, avoid combining several legs simply because they appear likely to win individually. Every additional leg increases the chance of losing the entire ticket. Compare alternate lines, review the payout, and bet only when the price makes sense.

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