NFL Football Betting Odds & Predictions for Week 4

We hit the quarter-mark of the season with plenty of chaos already: underdogs surprising, quarterbacks nursing bumps, and prop markets adjusting daily. This week’s slate features marquee matchups like Chiefs vs. Ravens, Eagles vs. Buccaneers, Packers vs. Cowboys, and a Thursday night opener that sets the tone. Whether you play spreads, props, parlays, or just want the best angles — this week demands precision. Let’s get into it.

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(Odds may shift leading up to kickoff, so be sure to double-check closer to game time.)

Sunday Early Games (1:00 p.m. ET)

Lions @ Browns

  • Line: Lions −9.5, Total ~44.5
  • Key Notes: Browns offense still sketchy; Detroit’s offense is gaining flow.
  • Prediction: Lions 35, Browns 14

Texans @ Titans

  • Line: Texans −7, Total ~39.5
  • Notes: Titans’ rookie QB has been under siege; Houston’s pass rush is a strength.
  • Prediction: Texans 28, Titans 17

Giants @ Chargers

  • Line: Chargers −6, Total ~43.5
  • Notes: Chargers are 3-0; Giants still searching.
  • Prediction: Chargers 27, Giants 14

Sunday Afternoon Games

49ers vs. Jaguars

  • Line: 49ers −3.5, Total ~46.5
  • Notes: San Francisco is undefeated; Jaguars have flashes but turnover risk.
  • Prediction: 49ers 28, Jaguars 19

Rams @ Colts

  • Line: Rams −3.5, Total ~49.5
  • Notes: Rams need bounce back; Colts defense has vulnerabilities.
  • Prediction: Rams 29, Colts 17

Raiders @ Bears

  • Line: Raiders −1.5, Total ~47.5
  • Notes: Bears’ defense is shaky; Raiders are more settled.
  • Prediction: Raiders 22, Bears 20

Chiefs vs. Ravens

  • Line: Ravens −2.5, Total ~48.5
  • Notes: High drama here — Mahomes vs Jackson. Chiefs defense is pressing to force turnovers.
  • Prediction: Ravens 24, Chiefs 23

Cowboys vs. Packers (Sunday Night)

  • Line: Packers −7, Total ~47.5
  • Notes: Micah Parsons returns vs former team; Cowboys miss CeeDee Lamb, elevating Jalen Cropper.
  • Prediction: Packers 29, Cowboys 18

Dolphins vs. Jets

  • Line: Dolphins −2.5, Total ~45.5
  • Notes: Jets still inconsistent; Dolphins have more balance.
  • Prediction: Dolphins 27, Jets 20

Broncos vs. Bengals

  • Line: Broncos −7.5, Total ~44.5
  • Notes: Bengals may struggle with backup QB issues; Denver healthy run game.
  • Prediction: Broncos 24, Bengals 17

Monday Night Football

Commanders vs. Falcons

  • Line: Commanders −1.5
  • Total: ~45.5
  • Notes: Tight divisional battle. Washington’s defense can cause problems; Atlanta’s offense has big-play ability.
  • Prediction: Commanders 27, Falcons 23

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Featured Game of the Week: Chiefs vs. Ravens

This is the one I’m circling. Two elite QBs, contrasting styles, and one spot that could swing playoff narratives in the AFC.

  • Line: Ravens −2.5
  • Total: 48.5
  • Key Notes: Chiefs have pushed a turnover-forcing agenda; Orioles are focused on disrupting Lamar Jackson’s rhythm. Baltimore’s offense is explosive but not perfect on the road.
  • Exact Score Prediction: Ravens 24, Chiefs 23
  • Parlay Ideas:
    • Ravens ML + Under 48.5
    • Jackson Over 225 rushing yards + Mahomes Under 300 passing yards
    • Mark Andrews anytime TD + Raven ML

Top Player Props to Watch

  • Chris Olave 6+ receptions vs. Bills — Saints rely on Olave heavily in volume offense.
  • Jordan Love Over 231.5 passing yards vs. Cowboys — Cowboys’ pass defense has allowed big yardage.
  • Bo Nix Under 220.5 passing yards — Bengals defense is tough against inexperienced QBs.
  • Travis Kelce Over 4.5 receptions in Chiefs matchup — Giants’ soft middle coverage invites TE targets.
  • Jonathan Taylor Over 88.5 rushing yards vs. Titans — Colts lean into the run game in favorable matchups.

Betting Strategy & Value Plays

  • Back 49ers −3.5 — they’ve shown consistency and depth against teams with turnover risk.
  • Ravens ML looks tight but sharp given the Mahomes matchup and pressure on Chiefs defense to make plays.
  • Use alternate lines: Packers −10, Lions −12.5, Rams −7.5 in games where injury reports or weather skew things.
  • Stack props conservatively in big games: in Chiefs vs Ravens, pair Jackson’s rushing yard over + Mahomes under rather than heavy multiples.
  • Be aggressive on receiving props in shootouts like Olave, Kelce, or Taylor — these can punch outsized value when lines are light.

Picks Summary

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  • Seahawks +1.5 (TNF)
  • Lions −9.5
  • Texans −7
  • Chargers −6
  • 49ers −3.5
  • Rams −3.5
  • Raiders −1.5
  • Ravens −2.5
  • Packers −7
  • Dolphins −2.5
  • Broncos −7.5
  • Commanders −1.5

Player props I’ll back: Olave receptions; Love passing over; Kelce receptions; Taylor rushing over


Thursday Night Football

Seahawks @ Cardinals

  • Line: Seahawks −1.5
  • Total: ~43.5
  • Notes / Lean: This NFC West opener is a punchy matchup. Arizona will try to leverage home crowd and run game; Seattle will push pace. Lean Cardinals +1.5 as a small underdog play, especially if weather or wind factors come into play.
  • Parlay Splash: Kyler Murray Over 225 passing yards + Cardinals ML

Disclaimer: This article is for informational purposes only and does not constitute betting advice.

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