Thursday Night Football Week 4 Betting Odds & Predictions – Arizona Cardinals vs. Seattle Seahawks 

Week 4 brings an NFC West showdown: the Arizona Cardinals (2-1) host the Seattle Seahawks (2-1) at State Farm Stadium. Kickoff is scheduled for 8:15 p.m. ET (5:15 p.m. local). Key names to watch: Kyler Murray and Trey Benson in Arizona; Sam Darnold, Jaxon Smith-Njigba, and Kenneth Walker III for Seattle.
(Odds may shift leading up to kickoff, so be sure to double-check closer to game time.)

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Game Preview

  • Arizona Cardinals:
    The Cards are dealing with a pivotal injury: James Conner is out, elevating Trey Benson into a larger role. Arizona will lean more on its passing game with tight end Trey McBride and WR Marvin Harrison Jr. expected to see extra attention. The defense has shown vulnerability against deep passes, and Seattle has the weapons to exploit that.
  • Seattle Seahawks:
    Seattle is riding momentum. Sam Darnold has settled in nicely, and Jaxon Smith-Njigba continues to produce big numbers. Kenneth Walker III provides balance with his running and passing game threat. Defensively, Seattle is solid at home and has historically played well on the road under their current staff. They can pressure Kyler Murray and tighten passing lanes.
  • Storylines:
    • Can Arizona’s offense adjust post-Conner injury?
    • Seattle’s aerial attack vs. Arizona’s secondary mismatch.
    • The urgency in a tight division early in the season.

Betting Odds Snapshot

  • Spread: Seahawks −1.5 (−108) | Cardinals +1.5 (−112)
  • Moneyline: Seahawks −122 | Cardinals +102
  • Over / Under (Total Points): 43.5 (Over −105 | Under −115)

These are current market odds (e.g. DraftKings, etc.). Expect movement as injury reports and public betting action roll in.


Props & Player Predictions

Here are standout prop bet ideas and predictions based on current lines and matchup dynamics:

Player PropPrediction
Jaxon Smith-Njigba Over 84.5 Receiving YardsHe’s been dominant; FanDuel has this line as −114.
Trey Benson Over 20.5 Receiving YardsWith Conner out, Benson’s usage in the passing game should spike.
Kyler Murray Under 212.5 Passing YardsSeattle’s pass defense and pressure potential make this feasible.
Trey McBride Over 61.5 Receiving YardsHe’s a safety valve, and Arizona will lean on him heavily with Conner gone.
Sam Darnold Over 223.5 Passing YardsComputer projections and matchup suggest he’ll exceed this.

Same-Game Parlay Idea (High Risk / Higher Reward)

  • Seahawks −1.5
  • Jaxon Smith-Njigba Over 84.5 Receiving Yards
  • Sam Darnold Over 223.5 Passing Yards

This potential betting combination targets Seattle to win outright, with Darnold and JSN putting up big numbers. Riskier but high upside.


Final Prediction

Seattle 27, Arizona 20 — Seahawks cover the 1.5 and the game likely stays under 43.5. Lean especially on Seahawks −1.5 and JSN Over 84.5.

Bet on NFL games
Grab your first-deposit bonus – New Sportsbook customers receive up to $200 on top of their first deposit. Wager on the NFL Regular Season and receive a $500 free bet, Win or Lose!

Disclaimer: This article is for informational purposes only and does not constitute betting advice.

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